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Abstral is a medication used to treat breakthrough pain in cancer patients who are already taking and tolerating around-the-clock opioid therapy for their underlying chronic pain. Abstral is a sublingual (under the tongue) tablet that dissolves quickly to allow rapid absorption of the active ingredient, fentanyl. Fentanyl is a strong opioid medication that is similar to other opioids such as morphine, codeine, and hydrocodone. However, fentanyl is many times more potent than these other opioids.

Cancer patients often experience "breakthrough" pain - sudden, intense flares of pain that occur despite the use of around-the-clock opioid therapy. Breakthrough pain can be extremely debilitating and can significantly interfere with a patient's quality of life. Abstral is designed to provide quick relief from breakthrough pain episodes while minimizing the risk of side effects associated with other strong opioids such as drowsiness, nausea, and constipation.

Abstral should only be used by cancer patients who are already taking and tolerating an around-the-clock opioid therapy for their underlying chronic pain. This is because Abstral contains a very potent form of fentanyl which can cause serious side effects including respiratory depression (slow or shallow breathing), sedation, dizziness, and even death if not used properly. Patients should only take the recommended dose of Abstral and should not attempt to increase their dose without first talking to their healthcare provider.

If you are a cancer patient who has been prescribed Abstral for the treatment of breakthrough pain, it is important that you understand how to take this medication safely and effectively. Be sure to follow all instructions given to you by your healthcare provider. If you have any questions about Abstral or your treatment plan, be sure to ask your doctor or pharmacist for more information.

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Where does Abstral come from?

It is a quick-acting form of fentanyl, which is a strong opioid medication. Abstral comes in the form of a sublingual tablet, which dissolves under the tongue. It is typically taken when cancer pain cannot be controlled by other forms of pain relief. Cancer pain can be difficult to control because it can be constant and severe. Opioid medications like Abstral are typically used as part of a comprehensive pain management plan that may also include other types of pain relief, such as acetaminophen or non-steroidal anti-inflammatory drugs (NSAIDs). Cancer patients should work with their healthcare team to develop a plan that meets their individual needs. Abstral is manufactured by AstraZeneca and was approved by the U.S. Food and Drug Administration (FDA) in 2011.

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Will I be on Abstral forever?

However, in general, patients are typically only prescribed Abstral for a limited period of time while they are actively experiencing breakthrough pain. Once the patient's pain has been adequately controlled and they no longer require Abstral for breakthrough pain relief, they will be tapered off of the medication and transitioned to another form of pain management. Therefore, it is unlikely that a patient would be on Abstral forever, but rather only for as long as it is needed to provide effective pain relief.

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Abstral and schizophrenia

Breakthrough pain is a sudden, intense pain that occurs even though the patient is already taking other pain medications to control their overall pain. Abstral dissolves under the tongue, allowing the medication to be absorbed quickly into the bloodstream. While Abstral is an effective way to manage breakthrough pain, it also has a high potential for abuse and addiction. The quick absorption of the drug into the bloodstream can result in a rapid highs followed by an intense crash. This can lead people to take more of the drug than prescribed in order to chase the initial high, which can lead to overdose and death. People with schizophrenia are especially vulnerable to the dangers of Abstral abuse. The symptoms of schizophrenia can make it difficult for people to tell reality from fantasy, which can lead them to believe that they need higher and higher doses of Abstral in order to feel “normal”. The resulting cycle of abuse can be devastating, leading to serious health problems and even death.

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Why is Abstral so expensive in USA?

It is a Schedule II controlled substance in the United States due to its high potential for abuse and addiction. Abstral tablets are orally disintegrating, meaning they dissolve quickly on the tongue without water. They contain the active ingredient fentanyl, a powerful opioid painkiller that is 50-100 times more potent than morphine. Breakthrough cancer pain is defined as sudden, severe episodes of pain that occur despite around-the-clock treatment with long-acting opioids such as oxycodone or morphine. These episodes can be extremely debilitating and interfere with daily activities, sleep, and quality of life. Abstral is approved to treat breakthrough cancer pain in adults who are already taking opioids for their underlying chronic pain. Abstral tablets come in three strengths: 100 micrograms (mcg), 200 mcg, and 400 mcg. The recommended starting dose is based on the patient's current opioid dose and their response to previous doses of Abstral. The usual dose range is one to four tablets every four hours as needed for pain relief, up to a maximum of 12 tablets per day. While Abstral can be an effective treatment for breakthrough cancer pain, it comes with a risk of serious side effects including respiratory depression (slow breathing), overdose, and death. Because of this, Abstral is only available through a limited distribution program and must be prescribed by a certified healthcare provider who has completed special training on its proper use. Due to its potential for abuse and misuse, Abstral carries a Boxed Warning from the U.S. Food and Drug Administration (FDA). This warning highlights the risks of taking Abstral while pregnant or breastfeeding; using alcohol or other central nervous system depressants while taking Abstral; accidentally swallowing or inhaling crushed tablets; and storing or handling crushed tablets where young children or pets could access them (a single tablet can cause death in children). So why is Abstral so expensive? There are a few factors that play into the cost of any medication, but withAbstral specifically, there are some unique considerations at play. First, because it's classified as a Schedule II controlled substance in the U.S., there are additional regulations surrounding its production, prescribing, dispensing, and storage that add to its cost. Second, because it's such a potent medication (50-100 times more potent than morphine), it takes special precautions to manufacture safe products that meet FDA standards; this also adds to the cost. Finally, because it's only available through a limited distribution program due to its potential risks, there's less competition among pharmacies which can drive up the price even further

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What is a natural alternative to Abstral?

Herbal teas, such as chamomile or ginger tea, can be helpful in soothing the stomach. Eating smaller, more frequent meals can also help to ease nausea. Some people find relief by eating certain foods, such as dry crackers or toast. Other helpful measures include drinking clear or ice-cold liquids, resting in a cool room, and wearing loose clothing. People with more severe symptoms may need medication to control their nausea.

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Can Abstral be used as a antiparkinsonian medication?

It is not indicated for use as an antiparkinsonian medication. While it may provide some relief from parkinsonian symptoms such as tremor and rigidity, it is not an effective treatment for the underlying disease. Abstral should only be used under the supervision of a healthcare provider familiar with its use and potential risks.

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Does Abstral cause constipation?

It belongs to a class of medications called narcotic analgesics. Common side effects of Abstral include nausea, vomiting, constipation, headache, dizziness, lightheadedness, and drowsiness. Constipation is more common with Abstral than with other narcotic analgesics. The mechanism of action of Abstral is not completely understood but it is thought to work by binding to opioid receptors in the brain and spinal cord which reduces the perception of pain. If you are experiencing constipation while taking Abstral, there are a few things you can do to help relieve your symptoms. Make sure you are drinking plenty of fluids and eating a high fiber diet. You can also try over-the-counter laxatives such as Miralax or Colace. If your constipation persists or becomes severe, contact your healthcare provider for further guidance.

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